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Volodymyr Gerzanich Selected Research

Glyburide (Glibenclamide)

1/2021SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.
1/2020SUR1-TRPM4 channels, not KATP, mediate brain swelling following cerebral ischemia.
1/2019Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.
1/2018SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.
9/2017Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.
1/2017Glibenclamide pretreatment protects against chronic memory dysfunction and glial activation in rat cranial blast traumatic brain injury.
11/2015Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis.
11/2015A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.
8/2015Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts.
3/2015Glibenclamide for the treatment of ischemic and hemorrhagic stroke.
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Volodymyr Gerzanich Research Topics

Disease

16Edema (Dropsy)
11/2021 - 04/2006
14Brain Edema (Cerebral Edema)
11/2021 - 04/2006
13Stroke (Strokes)
10/2017 - 01/2003
12Ischemia
01/2020 - 02/2008
11Hemorrhage
05/2015 - 12/2008
9Spinal Cord Injuries (Spinal Cord Injury)
06/2022 - 08/2007
8Necrosis
02/2022 - 08/2007
8Brain Ischemia (Cerebral Ischemia)
01/2020 - 03/2012
8Traumatic Brain Injuries (Traumatic Brain Injury)
08/2019 - 12/2010
7Neuroinflammatory Diseases
01/2021 - 07/2012
7Ischemic Stroke
01/2018 - 04/2006
7Wounds and Injuries (Trauma)
01/2017 - 02/2008
7Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
01/2016 - 02/2009
7Hypoxia (Hypoxemia)
05/2015 - 08/2007
5Infarction (Infarctions)
10/2017 - 04/2006
5Hypertension (High Blood Pressure)
09/2007 - 01/2003
4Inflammation (Inflammations)
09/2017 - 02/2009
4Brain Diseases (Brain Disorder)
05/2015 - 12/2011
3Brain Injuries (Brain Injury)
01/2021 - 06/2003
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
08/2015 - 02/2009
2Hypothermia
06/2022 - 11/2015
2Cytokine Release Syndrome
02/2022 - 01/2022
2COVID-19
02/2022 - 01/2022
2Neurocognitive Disorders (Clerambault Syndrome)
10/2021 - 01/2021
2Pain (Aches)
01/2021 - 01/2019
2Gliosis
01/2021 - 09/2017
2Neuralgia (Stump Neuralgia)
01/2021 - 01/2019
2Contusions
01/2019 - 02/2012
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
09/2017 - 11/2015
2Hydrocephalus (Hydrocephaly)
08/2017 - 11/2016
2Cerebral Infarction
08/2015 - 09/2013
2Hemorrhagic Stroke
03/2015 - 10/2013
2Brain Contusion
10/2011 - 12/2009
1Peripheral Nerve Injuries
01/2021
1Hyperalgesia
01/2021
1Infections
12/2020
1Chronic Pain
08/2019
1Cerebral Hemorrhage
10/2018
1Hyperplasia
11/2016
1Disease Progression
11/2015
1Multiple Sclerosis
11/2015
1Weight Gain
11/2015

Drug/Important Bio-Agent (IBA)

27Glyburide (Glibenclamide)FDA LinkGeneric
01/2021 - 04/2006
21Sulfonylurea ReceptorsIBA
12/2020 - 04/2006
16Adenosine Triphosphate (ATP)IBA
10/2013 - 04/2006
11Proteins (Proteins, Gene)FDA Link
02/2022 - 01/2006
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2022 - 02/2009
4Explosive Agents (Explosives)IBA
08/2019 - 10/2011
4CationsIBA
08/2015 - 04/2006
4Immunoglobulin G (IgG)IBA
08/2015 - 02/2009
3CytokinesIBA
02/2022 - 12/2021
3Interleukin-6 (Interleukin 6)IBA
02/2022 - 01/2021
3Aquaporins (Water Channels)IBA
11/2021 - 02/2015
3Toll-Like Receptor 4IBA
12/2020 - 03/2015
3OligodeoxyribonucleotidesIBA
01/2020 - 04/2010
3Ion Channels (Ion Channel)IBA
01/2020 - 02/2014
3Tissue Plasminogen Activator (Alteplase)FDA Link
01/2018 - 09/2012
3Caspase 3 (Caspase-3)IBA
07/2012 - 02/2009
3Angiotensin IIIBA
01/2006 - 01/2003
2NF-kappa B (NF-kB)IBA
02/2022 - 07/2012
2HMGB1 Protein (HMG1)IBA
01/2022 - 01/2020
2ChemokinesIBA
01/2022 - 01/2021
26,7-dihydroxyflavoneIBA
10/2021 - 01/2021
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2021 - 09/2017
2LigandsIBA
01/2020 - 03/2015
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2020 - 01/2016
2Transient Receptor Potential ChannelsIBA
01/2019 - 08/2007
2ElementsIBA
10/2018 - 04/2014
2Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2018 - 09/2012
2Nitric Oxide Synthase (NO Synthase)IBA
09/2017 - 01/2016
2RiluzoleFDA LinkGeneric
11/2015 - 01/2012
2Pharmaceutical PreparationsIBA
03/2015 - 04/2014
2fluoro-jade CIBA
07/2012 - 10/2011
2AngiotensinsIBA
10/2003 - 05/2003
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
05/2003 - 01/2003
1dihydrocapsaicinIBA
06/2022
1Antiviral Agents (Antivirals)IBA
02/2022
1InflammasomesIBA
01/2022
1Protein SIBA
01/2022
1Recombinant ProteinsIBA
11/2021
1LipidsIBA
11/2021
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2021
1Chemokine CXCL1IBA
01/2021
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2021
1TamoxifenFDA LinkGeneric
01/2021
1vpr Gene ProductsIBA
12/2020
1brivaracetamIBA
01/2019
1Mannitol (Osmitrol)FDA LinkGeneric
10/2018
1endosulfineIBA
10/2017
1Sirolimus (Rapamycin)FDA Link
10/2017
1B-Cell Activating FactorIBA
09/2017
1Phosphotransferases (Kinase)IBA
08/2017
1LipopolysaccharidesIBA
01/2017
1Furosemide (Lasix)FDA LinkGeneric
11/2016
1Acetazolamide (Diamox)FDA LinkGeneric
11/2016
1Protein Isoforms (Isoforms)IBA
01/2016

Therapy/Procedure

7Therapeutics
11/2021 - 04/2014
2Decompressive Craniectomy
10/2015 - 03/2010
2Artificial Respiration (Mechanical Ventilation)
05/2015 - 12/2011
1Induced Hypothermia
06/2022